Patrol Sgt. Brent Johnson said a 2023 Freightliner tractor-trailer combination was traveling at a low speed when it a blue Chevrolet sedan slammed into the rear of the semitrailer.
Johnson said rescue crews worked roughly two hours to free the driver, 36-year-old Jessica Stover.
Stover, who was the only occupant, suffered serious but non-life-threatening injuries, according to the patrol.
The semi driver, Edems Cheristil, 36, of Mount Pleasant, Pennsylvania, was not injured. There was a second crash in the area, with no injuries, according to the state patrol.
The interstate was reopened about 6 p.m., ending an hourslong shut down.
The crash remains under investigation, according to the state patrol.