After 12:20 p.m., Greenville police and fire were called to the intersection of State Route 571 near SR 49 and the Shell gas station on reports of a train derailment.
Police on scene said the train was coming from an ethanol plant in Greenville.
Three tankers, fully loaded with ethanol, and several others jumped the tracks, police said.
“There is no threat, no hazmat issues that we are aware of,” Greenville Police Lieutenant Ryan Benge said.
Greenville police told News Center 7 that the train line, R.J. Coleman, won’t be here until early Wednesday morning to move the derailed cars.
Crews will be staying on scene all night to redirect traffic.