“She was surrounded by her closest family and fought with great strength, leaving us with a certainty of her never-ending joy of living and whatever adventures lie ahead. As iconic as she was on screen, she was an even more amazing mother and grandmother,” her children said.
“We are grateful to the incredible team of doctors and nurses at the Moffitt Cancer Center for their care.”
John Travolta posted on Instagram following news of Alley’s death, saying he loves her.
“Kirstie was one of the most special relationships I’ve ever had.I love you Kirstie. I know we will see each other again,” said Travolta.
Travolta starred in “Look Who’s Talking,” and “Look Who’s Talking too,” alongside Alley in 1989 and 1990, according to The Associated Press.
Alley was known for her role in “Cheers” as Rebecca Howe in 1990, which earned her a Golden Globe and Emmy, according to Biography.com. After “Cheers,” she won an Emmy for her role in a television movie called “David’s Mother” in 1994, and then was nominated for an Emmy for her supporting role in a dramatic miniseries called “The Last Don.”
In recent years, she as on multiple reality shows including “Dancing With the Stars,” according to the AP.
Alley was married to Parker Stevenson from 1983 to 1997 and together they adopted two children, William True and Lillie Price, according to Biography.com.
Kirstie Alley through the years NEW YORK, NY - JANUARY 13: Kirstie Alley attends "Constellations" Broadway opening night at Samuel J. Friedman Theatre on January 13, 2015 in New York City. (Photo by Andrew H. Walker/Getty Images) (Andrew H. Walker/Getty Images)
Kirstie Alley through the years BOREHAMWOOD, ENGLAND - SEPTEMBER 10: Runner up Kirstie Alley is evicted during the Celebrity Big Brother final 2018 at Elstree Studios on September 10, 2018 in Borehamwood, England. (Photo by Stuart C. Wilson/Getty Images) (Stuart C. Wilson/Getty Images)
Kirstie Alley through the years NEW YORK, NY - DECEMBER 03: Actress Kirstie Alley attends the "Kirstie" premiere party at Harlow on December 3, 2013 in New York City. (Photo by Robin Marchant/Getty Images) (Robin Marchant/Getty Images)
Kirstie Alley through the years NEW YORK, NY - DECEMBER 03: Actress Kirstie Alley attends the "Kirstie" premiere party at Harlow on December 3, 2013 in New York City. (Photo by Robin Marchant/Getty Images) (Robin Marchant/Getty Images)
Kirstie Alley through the years HOLLYWOOD, CALIFORNIA - AUGUST 22: Kirstie Alley and John Travolta attend the premiere of Quiver Distribution's "The Fanatic" at the Egyptian Theatre on August 22, 2019 in Hollywood, California. (Photo by Matt Winkelmeyer/Getty Images) (Matt Winkelmeyer/Getty Images)
Kirstie Alley through the years WEST HOLLYWOOD, CA - SEPTEMBER 19: Actress Kirstie Alley arrive at the Showtime Network post 56th Annual Primetime Emmy Party at Mortons Restaurant on September 19, 2004 in West Hollywood, California. (Photo by Frederick M. Brown/Getty Images) ( 01/ ��������������������)
Kirstie Alley through the years ANAHEIM, CA - MAY 07: Actress Kirstie Alley arrives at premiere of Walt Disney Pictures' 'Pirates of the Caribbean: On Stranger Tides' held at Disneyland on May 7, 2011 in Anaheim, California. Proceeds from the world premiere of Walt Disney Pictures' 'Pirates Of The Caribbean: On Stranger Tides' will benefit the Boys & Girls Clubs of America (Photo by Frazer Harrison/Getty Images) (Frazer Harrison/Getty Images)
Kirstie Alley through the years UNIVERSAL CITY, CA - JANUARY 12: Actor Kirstie Alley speaks during panel discussion of "Fat Actress" for the Showtime Network 2005 Television Critics Winter Press Tour at the Hilton Universal Hotel on January 12, 2005 in Universal City, California. (Photo by Frederick M. Brown/Getty Images) *** Local Caption *** Kirstie Alley (Frederick M. Brown)
Kirstie Alley through the years NEW YORK, NY - SEPTEMBER 13: Actress Kirstie Alley attends lia sophia celebrates "Social Fashion" and debuts "boudika" Red Carpet Collection at Empire Hotel on September 12, 2011 in New York City. (Photo by Anna Webber/Getty Images for lia sophia) (Anna Webber)
Kirstie Alley through the years LOS ANGELES, CA - MARCH 09: Professional dancer Maksim Chmerkovskiy and actress Kirstie Alley arrive to the opening of Kirstie Alley's Organic Liaison Store on March 9, 2011 in Los Angeles, California. (Photo by Alberto E. Rodriguez/Getty Images) (Alberto E. Rodriguez/Getty Images)